abstract：:Three cases of severe and irreversible alopecia occurring in patients with common variable immunodeficiency are described. In all three cases, hair loss developed after the diagnosis of immune deficiency; one of the patients also had extensive vitiligo. A fourth patient had vitiligo in the absence of alopecia. No chan...

journal_title：Postgraduate medical journal

authors： Spickett G,Prentice AG,Wallington T,Webster AD,Chapel H

更新日期：1991-03-01 00:00:00

abstract：:The treatment of renal anaemia by recombinant human erythropoietin (EPO) is now well established. Several studies have examined the pharmacokinetics and efficacy of the drug given intravenously, intraperitoneally and subcutaneously and there is increasing evidence that the subcutaneous route has several advantages inc...

journal_title：Postgraduate medical journal

authors： Macdougall IC,Hutton RD,Coles GA,Williams JD

更新日期：1991-01-01 00:00:00

abstract：:Five cases of strangulated femoral hernia, all with a delay in establishing the diagnosis, are reported here. These cases illustrate the continuing difficulties experienced, both in primary care and hospital practice, in making this diagnosis despite the clinical awareness of this condition. ...

journal_title：Postgraduate medical journal

authors： Heys SD,Brittenden J

更新日期：1991-01-01 00:00:00

abstract：:This short overview discusses circadian rhythms observed in cardiovascular events such as myocardial ischaemia and myocardial infarction, which occur most frequently in the morning. Changes in the frequency of occurrence seem to be related to, and may result from, circadian rhythms in factors such as heart rate, blood...

journal_title：Postgraduate medical journal

authors： Fox KM,Mulcahy DA

更新日期：1991-01-01 00:00:00

abstract：:It is a tragedy that morphine is scarcely available for between 1.3 and 2.5 billion people whilst 3.5 million cancer patients suffer needlessly. In only 10 countries is its consumption rising, in many more only codeine consumption shows an increase, and in many areas even in the Western world prescribing is grossly li...

journal_title：Postgraduate medical journal

authors： Doyle D

更新日期：1991-01-01 00:00:00

abstract：:Metabolic acidosis and hyperlactataemia are important, independent findings in acute illness, and the combination of these abnormalities carries a grave prognosis. Despite this there is still controversy about the most appropriate therapy of lactic acidosis, and the relationship of commonly used acid base measurements...

journal_title：Postgraduate medical journal

authors： Nimmo GR,Grant IS,Mackenzie SJ

更新日期：1991-01-01 00:00:00

abstract：:Asthma is an inflammatory disease characterized by infiltration of the airways by eosinophils and ensuing bronchial hyperresponsiveness. The activation of eosinophils and their recruitment to the airways are strongly influenced by T-lymphocytes and their products. There is now evidence that successful therapy of asthm...

journal_title：Postgraduate medical journal

authors： Milgrom H

更新日期：1991-01-01 00:00:00

abstract：:By comparison with other calcium antagonist drugs, amlodipine has unique pharmacokinetic properties that are probably attributable to its chemical structure and positive ionic charge at physiological pH. Thus, amlodipine undergoes gradual absorption from the gastro-intestinal tract and is widely distributed throughout...

journal_title：Postgraduate medical journal

authors： Elliott HL,Meredith PA

更新日期：1991-01-01 00:00:00

abstract：:The majority of second-generation calcium antagonists are dihydropyridines, some of which show vascular selectivity. Several new dihydropyridines have been developed with comparable pharmacodynamic properties to existing calcium antagonists in this class and greatly improved kinetic half-lives. Of these agents, amlodi...

journal_title：Postgraduate medical journal

authors： Opie LH

更新日期：1991-01-01 00:00:00

abstract：:Patients with coronary atherosclerosis present with angina, myocardial infarction and sudden death, most often caused by atherosclerotic stenosis complicated by spasm and/or occlusive thrombosis. All of these events have been shown to exhibit similar diurnal rhythms, with a peak incidence in the morning after waking a...

journal_title：Postgraduate medical journal

authors： Selwyn AP,Raby K,Vita JA,Ganz P,Yeung A

更新日期：1991-01-01 00:00:00

abstract：:Amlodipine is a dihydropyridine calcium antagonist with a unique pharmacokinetic profile providing advantages over other therapies of its kind. It has been shown to possess high oral absorption, long elimination half-life, smooth onset of action and long duration of pharmacodynamic activity. These properties result in...

journal_title：Postgraduate medical journal

authors： Taylor SH

更新日期：1991-01-01 00:00:00

abstract：:Infection with hepatitis B virus (HBV) is much more common in tropical than in temperate countries. Visitors to the tropics are thus at risk from HBV, though the degree of risk, and the routes of infection involved are uncertain. We report serological markers of HBV in two groups of 2nd World War soldiers, who served ...

journal_title：Postgraduate medical journal

authors： Gill GV,Bell DR,Vandervelde EM

更新日期：1991-01-01 00:00:00

abstract：:Two young patients with sickle cell trait (AS haemaglobinopathy) and ischaemic stroke are reported. The stroke involved the internal carotid artery territory in one and the brainstem in the other. A review of the literature is presented to suggest that the association of sickle cell trait and cerebral infarction is mo...

journal_title：Postgraduate medical journal

authors： Radhakrishnan K,Thacker AK,Maloo JC,el-Mangoush MA

更新日期：1990-12-01 00:00:00

abstract：:The present anti-racial discrimination legislation in the United Kingdom is embodied in the 1976 Race Relations Act. In essence this Act attempts to avoid any form of direct or indirect discrimination on the basis of racial or ethnic origin. However, health professionals are acutely aware that there are important raci...

journal_title：Postgraduate medical journal

authors： Bedi R,MacEwen M

更新日期：1990-12-01 00:00:00

abstract：:A 32 year old man with alcohol-induced pain over a right submandibular swelling is described. Excision biopsy of this swelling revealed chronic sialadenitis and the symptoms promptly ceased following this excision. We speculate on the possible pathophysiological mechanism. ...

journal_title：Postgraduate medical journal

authors： Okany CC,Akinsete I,Akinyanju OO

更新日期：1990-11-01 00:00:00

abstract：:This report describes the case history of a middle-aged lady who presented with symptoms and signs over one year leading to a diagnosis of multiple sclerosis. During one of her relapses, she developed trismus--an association that has not been described before in multiple sclerosis. ...

journal_title：Postgraduate medical journal

authors： D'Costa DF,Vania AK,Millac PA

更新日期：1990-10-01 00:00:00

abstract：:Eight patients with endobronchial tuberculosis diagnosed on bronchoscopy were treated with antituberculosis drugs and a course of prednisone. The progress of the endobronchial lesions was assessed on repeated examinations. The course of the disease was variable and the endobronchial narrowing improved in two patients ...

journal_title：Postgraduate medical journal

authors： Chan HS,Sun A,Hoheisel GB

更新日期：1990-10-01 00:00:00

abstract：:We report the case of a young man with Fusobacterium necrophorum meningitis who developed bilateral carotid artery stenosis associated with thrombosis of the cavernous sinuses. Intraluminal clot was present in the region of the stenoses for which he was anticoagulated. The clinical presentation, problems with diagnosi...

journal_title：Postgraduate medical journal

authors： Jones TH,Bergvall V,Bradshaw JP

更新日期：1990-09-01 00:00:00

abstract：:Thirteen patients with mild primary hyperparathyroidism who were taking thiazide diuretics intermittently for periods of up to 18 months were followed up for a mean of 5.3 years. No significant difference was found in either plasma total calcium corrected for albumin or whole blood ionized calcium in these patients be...

journal_title：Postgraduate medical journal

authors： Farquhar CW,Spathis GS,Barron JL,Levin GE

更新日期：1990-09-01 00:00:00

abstract：:This study assesses the economic benefits of misoprostol in the prophylaxis of gastric ulcers larger than 0.3 cm in patients with osteoarthritis receiving non-steroidal anti-inflammatory drugs. Independent epidemiological data were obtained for patients in Scotland and the West Midlands. Co-diagnosis of arthritis with...

journal_title：Postgraduate medical journal

authors： Knill-Jones R,Drummond M,Kohli H,Davies L

更新日期：1990-08-01 00:00:00

abstract：:Central venous catheterization is not without hazard. Inadvertent placement in the pleural space can occur without the development of a pneumothorax and pressure measurements may appear misleadingly normal. This case report illustrates an effective method of diagnosing and draining an iatrogenic hydrothorax which resu...

journal_title：Postgraduate medical journal

authors： Steiger MJ,Morgan AG

更新日期：1990-08-01 00:00:00

abstract：:Forty-five healthy men aged 21-34 years took part in a double-blind, parallel-group, placebo-controlled study of the effects of 28 days' treatment with lornoxicam 4 mg twice daily or indomethacin 50 mg twice daily on faecal blood loss and the endoscopic appearances of gastric and duodenal mucosa. After an initial endo...

journal_title：Postgraduate medical journal

authors： Warrington SJ,Debbas NM,Farthing M,Horton M,Johnston A,Thillainayagam A,Turner P,Ferber H

更新日期：1990-08-01 00:00:00

abstract：:A case of skin necrosis at the sites of injection of subcutaneous heparin is described. The patient went on to develop heparin-induced thrombocytopenia and pulmonary embolism. Review of the previously described cases of heparin-associated skin necrosis reveals that this sequence of events is not uncommon. ...

journal_title：Postgraduate medical journal

authors： Fowlie J,Stanton PD,Anderson JR

更新日期：1990-07-01 00:00:00

abstract：:The characteristics of three combinations of thiopentone and etomidate [in the ratios of thiopentone (mg):etomidate (mg) of 5:1, 13:1 and 25:1] have been compared with the individual agents alone for the induction of anaesthesia. The incidence of pain on injection and abnormal movements was less with the combination c...

journal_title：Postgraduate medical journal

authors： Slater RM,Pollard BJ,Young TM,Hunt LP

更新日期：1990-07-01 00:00:00

abstract：:A 17 year old woman presented with severe anaemia due to menorrhagia. On investigation, she was shown to have abnormalities of her haemostatic mechanism consistent with von Willebrand's disease Type I, although there was no family history of this disorder. In addition, she was shown to have severe primary hypothyroidi...

journal_title：Postgraduate medical journal

authors： Blesing NE,Hambley H,McDonald GA

更新日期：1990-06-01 00:00:00

abstract：:We report a patient who developed persistent nephrogenic diabetes insipidus associated with renal tubular acidosis, renal resistance to parathyroid hormone, aminoaciduria and proximal tubule pattern proteinuria in the presence of a reduced glomerular filtration rate (19-24 ml/min). A review of the previous reports of ...

journal_title：Postgraduate medical journal

authors： Neithercut WD,Spooner RJ,Hendry A,Dagg JH

更新日期：1990-06-01 00:00:00

abstract：:It is argued that as the major occupational cancer risks become matters of historical interest, research epidemiologists working in the field should broaden their approaches to encompass life style factors. In the investigation of possible low-cancer risks, it no longer makes any sense to confine their data-collecting...

journal_title：Postgraduate medical journal

authors： Roe FJ

更新日期：1990-05-01 00:00:00

abstract：:Prolonged coma resulting from hypoxic brain injury is usually associated with a dismal chance of return to independent existence. In this report a case is described of a 60 year old man who recovered and returned to work as a university professor after being in a vegetative state at least 8 weeks after a prolonged cer...

journal_title：Postgraduate medical journal

authors： Falk RH

更新日期：1990-05-01 00:00:00

abstract：:Two patients, one of whom was pregnant, developed superior vena caval thrombosis while receiving central parenteral nutrition. They were successfully treated with recombinant tissue plasminogen activator (t-PA). ...

journal_title：Postgraduate medical journal

authors： Barclay GR,Allen K,Pennington CR

更新日期：1990-05-01 00:00:00

abstract：:A case of adenocarcinoma of the lung, in which high titre anticardiolipin antibodies were associated with recurrent venous thromboses resistant to all forms of therapy, is described. It is suggested that such an autoimmune response may be a contributory factor in the para-neoplastic development of vascular thromboses....

journal_title：Postgraduate medical journal

authors： Shaukat MN,Hughes P

更新日期：1990-04-01 00:00:00

abstract：:The presenting features of 250 consecutive patients who underwent a ventilation/perfusion lung scan for suspected pulmonary embolus (PE) were analysed. Ninety-six patients had lung scans highly suggestive of PE, with one or more unmatched segmental perfusion defects (scan positive), 86 had low probability scans (scan ...

journal_title：Postgraduate medical journal

authors： Fennerty AG,Shetty HG,Paton D,Roberts G,Routledge PA,Campbell IA

更新日期：1990-04-01 00:00:00

abstract：:We report three cases of a distinctive palmar-plantar erythema associated with the treatment of non-Hodgkin's lymphoma and acute myeloid leukaemia. The rash is characterized by a painful, sharply demarcated, intense erythema of the palms and/or soles followed by bulla formation, desquamation and healing. The eruption ...

journal_title：Postgraduate medical journal

authors： Pagliuca A,Kaczmarski R,Mufti GJ

更新日期：1990-03-01 00:00:00

abstract：:Patients with Cushing's syndrome rarely become pregnant. This is a high risk situation both for the fetus and the mother, if untreated. We report a patient with Cushing's syndrome due to adrenocortical adenoma who became pregnant and was successfully treated with ketoconazole during the last period of pregnancy. ...

journal_title：Postgraduate medical journal

authors： Amado JA,Pesquera C,Gonzalez EM,Otero M,Freijanes J,Alvarez A

更新日期：1990-03-01 00:00:00

abstract：:We describe a case of severe septicaemia caused by Mycoplasma hominis in a 23 year old patient following childbirth. She developed disseminated intravascular coagulation and acute respiratory distress syndrome which have not hitherto been described in association with septicaemia due to this organism. Investigation an...

journal_title：Postgraduate medical journal

authors： Young MJ,Cox RA

更新日期：1990-02-01 00:00:00

abstract：:Two hundred and sixty one patients attending a geriatric service were asked to give details of their usual medications without reference to drug bottles or written lists. Recall was tested in 4 categories: name of drugs, drug dosage, frequency of administration, and reason for the drug being prescribed. Drug recall wa...

journal_title：Postgraduate medical journal

authors： al Mahdy H,Seymour DG

更新日期：1990-02-01 00:00:00

abstract：:A patient with calcific constrictive pericarditis due to rheumatoid arthritis is presented: the literature reveals only one previous case which was attributed to the long duration of the rheumatoid arthritis. ...

journal_title：Postgraduate medical journal

authors： Manji H,Raven P

更新日期：1990-01-01 00:00:00

abstract：:Three studies reported here have confirmed that lornoxicam is effective in osteoarthritis and the ideal dose appears to be 12 mg daily. Overall, lornoxicam appears to be a useful drug in the treatment of both osteo- and rheumatoid arthritis, from the data presently available. ...

journal_title：Postgraduate medical journal

authors： Berry H,Ollier S

更新日期：1990-01-01 00:00:00

abstract：:We report the case of a patient with multiple myeloma who developed acute life-threatening water intoxication following treatment with oral indomethacin and low dose intravenous cyclophosphamide. We describe a possible drug interaction between these two drugs and recommend that they should only be used together with c...

journal_title：Postgraduate medical journal

authors： Webberley MJ,Murray JA

更新日期：1989-12-01 00:00:00

abstract：:Four cases of severe osteolysis of bones subsequent to camel bite are described. The first had osteolysis of the ribs with traumatic diaphragmatic hernia. Two cases had similar appearances of gross osteolysis of the shafts of the radius and ulna, whilst one had osteolysis of the humeral shaft. The similarities in the ...

journal_title：Postgraduate medical journal

authors： al-Boukai AA,Hawass NE,Patel PJ,Kolawole TM

更新日期：1989-12-01 00:00:00

abstract：:A 60 year old woman with computed tomographic-verified bilateral thalamic infarction is described. She demonstrated downward gaze paralysis, amnesia and hypersomnolence. On the functional level such tasks as walking and eating were disconcerting. Although there have been only a few reports of the complete triad it may...

journal_title：Postgraduate medical journal

authors： Nagaratnam N,Ghougassian DF,Mugridge V

更新日期：1989-11-01 00:00:00